Endocrine Abstracts

Background: Since it has been shown that markers of oxidative stress persist in endothelial cells that have been exposed for a prolonged time to chronic constant high glucose levels, long after glucose normalization, a phenomenon defined as ‘metabolic memory’, evaluation of chronic exposure to oscillating high glucose, its impact on the induction of cellular stress markers and the onset of a ‘metabolic memory’ might be of pivotal interest. In doing so we al...

Background and objectives: Obesity-associated inflammation is a key contributory factor in the pathogenesis of type 2 diabetes mellitus (T2DM). Murine studies have revealed potential links between obesity-induced activation of the innate immune response and endoplasmic reticular (ER) stress. Our aims were therefore to (1) examine whether human abdominal subcutaneous (AbSc) adipose tissue (AT) obtained from lean and obese patients, differs in the level of ER stress, through ass...